Degradation of cartilage and synovial fluid in the joints that prevents friction between the bones leading to constant pain & limited joint movement. Over 242M people are currently living with symptomatic and activity-limiting osteoarthritis (OA).

Current treatment options are inadequate:

• Pain medication – only provides temporary pain management
• Orthotics/Knee braces – discomfort & mixed results
• Total joint replacement – invasive, costly and an end of the line necessity
• Viscosupplementation (Intra-articular injections) – effective but degrades quickly

PolyZen™ is a zwitterionic in situ gelling hydrogel.

• The zwitterionic component provides excellent antifouling properties that lead to high lubrication that mimics native and healthy synovial fluid
• The in-situ gelling mechanism allows us to tailor physiochemical properties such as degradation rate and compressive strength
• This combination of properties allows for both lubrication and mechanical support that is otherwise unavailable in a single package

Synovial Fluid

PolyZen™ exhibits the same fluid properties as healthy and natural synovial fluid & provides lubrication even under severe OA simulations.

Tunable viscosity to match synovial fluid viscosity ranges

Significantly better lubrication than leading hyaluronic acid-based viscosupplements

Cartilage

The elasticity of PolyZen™ hydrogels can be customized to levels closer to the human cartilage compared to the HA-based hydrogels